DCA dosage and usage (Quick guide)

1. DOSAGE Recommended DCA daily dose is 20 mg/kg daily (milligrams per human body kilogram per day).Calculation of dosage for a particular person is simple: just multiply your weight by 20 mg/kg and you will get daily DCA dose in milligrams. For example - if the person weighs 75 kg:75 kg x 20 mg/kg = 1500 milligrams daily = 1.5 grams of DCA daily (5 capsules of 333 mg or 3 capsules of 500 mg) The weight of the person should be taken excluding overweight. MINIMAL DOSEMinimal therapeutically effective DCA daily dose is two times smaller - 10 mg/kg daily. Smaller amount is not recommended as the drug may have little to no effect. MAXIMAL DOSEIn case there are no side effects, DCA dosage may be increased to 30-40 mg/kg daily.In case of strong side effects daily dose should be reduced to 10-20 mg/kg daily. 2. MEASURING DCA POWDER The most accurate way to measure DCA powder is by water solution. It is best to prepare a solution containing 0,1 g of DCA powder in 1 ml of water solution. 1. Put 25 grams of DCA into 250 ml bottle (alternatively 50 grams into 500 ml, or 100 grams into 1000 ml). WARNING: remove and dispose of the desiccant packet, if there is one inside. 2. Pour cool distilled water till it reaches the 250 ml point. 3. Close the bottle and shake it until the powder dissolves. 4. This way 1 ml of solution will hold 0,1g of Sodium Dichloroacetate 1 milliliter DCA solution = 0,1 gram powder DCA DCA solution, ml12345678910DCA powder, g0,10,20,30,40,50,60,70,80,91,0 3. DCA SCHEDULE DCA should be taken 2 times a day with food. One half in the morning, the second half in the evening. For example, if a person weights 80 kg and takes 2 grams (6 capsules) daily, he should take 1 gram (3 capsules) with breakfast and 1 gram (3 capsules)  with dinner. During the first week of the treatment take smaller doses: Day% of daily doseDay 125%Day 250%Day 375%Day 475%Day 575%Day 6BreakDay 7Break If using DCA doesn‘t cause any unwanted side effects, next week start taking the full dose. There are two known schemes for DCA usage:A) Take full daily doses of DCA for five days straight and then take a break for two days. Repeat this routine every new week. (old way)B) Take full daily doses of DCA every day for two weeks and then take one week off. This scheme could be more beneficial when seeking a better antitumor effect. (new way) 4. THE DURATION OF TREATMENT Best results are to be expected in stage 1, 2 and 3 cancer. STAGE 1 - 2: Usually about 2 - 3 months, depending on the results.Take scans and tests often to monitor your cancer.Recurrence prevention: in case of remission, it is recommended to take DCA periodically (for about 6 weeks every 18 months or so). Tests should be taken, and, if there is a need, the frequency of DCA treatment may be increased. STAGE 1, 2 or 3, IN CASE OF SURGERY WHERE ALL OR MOST OF THE TUMOR…

DCA papers and clinical trials

For almost a decade there has been a growing interest in Dicholoroacetates potential to successfully get rid of cancer while causing minimal harm to healthy organs. DCA is a relatively cheap substance which cannot be patented by the pharmaceutical industry, thus it could not generate profit for private drug companies. Right now, because of this reason, Dichloroacetate isn't receiving enough funding and attention which it deserves. Despite that, there are plenty of ongoing and completed studies which examine the facts of DCA appliance for therapy. This site will present a handful of completed scientific investigations and will constantly update you with the most recent publications related to the subject. Below you can find full research reports of Sodium Dichoroacetate (DCA) as an anti-cancer agent.

Methods and supplements for preventing DCA side effects

When you begin your Sodium dichloroacetate regimen, it is crucial that you take supplementation which provides protective benefits. This way you minimize the chance for developingr reversible peripheral neuropathy as well as other adverse reactions related to the nervous system. Below you will find a list of supplements which are essential or recommended for a pleasant DCA usage experience with the lowest achievable side effect probability. ▪ Vitamin B1 – thiamine.(Necessary)(take one and a half 100mg capsules / tablets twice a day. Take it before breakfast and before lunch.An alternative way - take 100 mg three times a day. Total - 300 mg) The B group vitamin thiamine appears to have a protective effect against peripheral neuropathy. This food supplement can be used not only for DCA induced neuropathy but also for other neuropathies which are caused by diabetes and chronic alcohol abuse. (Ref.)We recommend using benfotiamine because it can be absorbed over five times better than the ordinary thiamine form. In addition, the newest research claims that Vitamin B1 can have an antiproliferative effect on malignant cells. (Ref.) ▪ Alpha–Lipoic acid. (Necessary)(take one 300 mg R+/S- capsule/tablet three times a day or take one 150 mg R+ capsule/tablet three times a day. Take it before breakfast, before lunch and before dinner. Total - 900 mg (R+/S-) or 450 mg (R+))α-Lipoic acid is a strong antioxidant, it helps avoiding and controlling symptoms related to neuropathy. The supplement can lower anxiety, memory problems as well as help keeping away from peripheral neuropathy manifestations such as tingling, burning, painful sensations and numbness. (Ref.)You can use smaller doses if you're taking R-form α-Lipoic acid.If you have Racemate α-Lipoic acid (which is a mix of R and L forms), you should take a twice larger dose to fulfill your daily goal. ! Don't take α-Lipoic acid if you're receiving chemotherapy or radiotherapy.α-Lipoic acid has a strong antioxidative effect that can interfere with the effectiveness of chemotherapy. For this reason, we recommend staying away from this supplement a couple of days before the chemo, during the treatment and 1 week after the chemotherapy. (Ref.)α-Lipoic acid also can decrease the effectiveness of radiotherapy. This is why we recommend avoiding taking it for several days before, during and 2 week after these procedures. ▪ Acetyl L-Carnitine. (Recommended)(take on 600mg capsule / tablet three times a day. Take it before breakfast, before lunch and before dinner. Total - 1800 mg)The majority of scientific studies claims that Carnitine can be an effective aid to lower peripheral neuropathy. Acetyl L-Carnitine is also an attractive option because its longtime usage does not cause any side effects and carries no health risk. (Ref1.), (Ref2.), (Ref3.)α-Lipoic acid and Acetyl L-Carnitine both appear to have a synergistic effect at preventing neuropathy. On rare occasions, Sodium dichloroacetate administration can result in heartburn or nausea. If this is the case, try taking DCA after you eat a little bit of food and drink some fluids to avoid your stomach becoming irritated.If that didin't resolve the problem, you should try taking medications that lower gastric acid secretion - proton pump inhibitors.Any type of PPI is acceptable provided the fact that…

DCA safety and side effects

Sodium dichloroacetate is considered to be a fairly safe alternative cancer treatment. There have been no cases recorded for DCA to be a cause of death.Before we begin, we should bear in mind that Sodium dicholoroacetate has already demonstrated  success in dealing with ‘‘Lactic acidosis in children with congenital mitochondrial defects“  for some time. The first scientific studies and the usage of the drug began over 40 years ago. (Ref.)In this time period, DCA has been constantly used as a medication for congenital mitochondrial diseases. The research done by Peter Stacpoole and his colleagues proved that when used for therapy, Sodium dichloroacetate can cause none, mild or moderate side effects. (Ref.)The probability of adverse reactions is dependent on the dosing and the age of the patient. Larger DCA doses and  older patient age (above 40 years) are related to a higher side effect occurrence. (Ref.)On exceptionally rare occasions, a small portion of the population can metabolize DCA more slowly than the average. For this reason, even the standard DCA doses can cause adverse reactions to appear faster and more prominent in this group of people. In this case, lowering the DCA dose should fix the issues.If you stop taking DCA, almost all of the side effects disappear in less than a week. The reversible peripheral neuropathy can sometimes take up to 7 or 14 days (rarely) to resolve completely. (Ref.) According to one of the most famous DCA clinics and their observational data, 44 % of the patients who have taken DCA did not experience side effects. The most common side effects caused by Dichloroacetate: ▪ Peripheral neuropathy.  (experienced by up to 20% of people who use DCA). This group of symptoms begins in the fingers, hands and feet. Depending on the intensity of the neuropathy, it can manifest as tingling, numbness, tremor, painful sensations and slightly increased difficulty of coordinated movement.On less common occasions, neuropathy can emerge in other places and appear as the tingling of eyes, lips and tongue. Typically, at least a couple of weeks or months are needed for peripheral neuropathy to develop.This side effect is reversible – its intensity can decrease or it can disappear completely upon lowering the DCA dose or stopping DCA usage. (Ref.) At the bottom of the article you will find information about the supplements and methods you can apply to avoid this adverse reaction. ▪ Sleepiness, mental fogginess, confusion  (experienced by up to 20% of people who use DCA). This group of symptoms is reversible – you can decrease their intensity or completely make them disappear by lowering the DCA dose or stopping DCA usage. The rare side effects caused by Dichloroacetate: ▪ Heartburn, nausea, digestive disorders. Administering Dichloroacetate through the mouth can sometimes cause GI irritability. At the bottom of the article you will find information about the supplements and methods you can apply to avoid this adverse reaction. ▪ Pain at the tumor site (temporary and then resolves). A very rare adverse reaction. It indicates that due increased apoptosis a lot of cancer cells are dying and indicates that DCA therapy is effective. However, only a…

DCA dosage and usage (Long guide)

DCA doses and how to count themThe usage of DCA powder and capsulesHow to store DCA ?DCA administration scheduleExample 2007 was a huge year for Dichloroacetate and cancer. A group of researchers found out that this old orphan drug could be a promising selective anticancer agent as it significantly shrunk DCA-treated tumors. (Ref.)Naturally, the next question - what doses of Sodium dichloroacetate could be safe and effective for treatment ?As luck would have it, the substance, Dichloroacetate, has been used as a medication for treating other conditions for more than several decades. All of the research regarding the dosing size, side effects as well as the long term safety have been already completed. (Ref1.), (Ref2.)One should bear in mind these two important principles when starting DCA therapy:1) You should always begin with a smaller dose. After the first DCA cycle (eg. a week or three weeks) when you’re sure that DCA is well tolerated, the dose can be increased to normal.2) Vit B1. and ALA supplements are a must. They serve brilliantly to decrease the probability of side effects and their intensity. When you use DCA smartly and responsibly, the whole experience is more likely to be safe and sound. In this case, you can even use higher Sodium dichloroacetate doses, avoid discomfort and achieve better results.  You can read more about the subject on DCA safety and side effects. DOSAGE Sodium dichloroacetate can be used in two different ways – intravenously or through oral administration. Depending on the route of administration, there are different rules, doses and usage patterns.We’ll mainly talk about the easier alternative, DCA usage through the mouth.The formula for counting your daily dose:A kg x B mg/kg = C mg(Body weight x Dose size= Daily DCA dose)A – This is your body weight. It should be counted without the excess body weight. Excess body weight is defined as the amount of weight that is in excess of the ideal body weight (BMI 18,5 – 24,9).Ideal body weight is conventionally determined by the Metropolitan Life Tables, or as a BMI of <25 kg/m2.For example, if you‘re 5'11”/ 180 cm tall and you weigh 100 kg (220 lb), then you should enter 81 kg (178,5 lb) to the formula.To find out your ideal body weight based on your height, visit this site – link. B – These are the standard dose norms. The ordinary DCA dose is 25 mg/kg, the lowest effective DCA dose is 10 mg/kg, the highest DCA dose is 50 mg/kg a day. C –  This is your daily DCA dose. You have to take the half of this before breakfast and the other half before dinner. We’ll give you a quick example just to make things clear:Let’s assume that you weight 75 kg (165 lb):75 kg x 10 mg/kg = 750 mg (first DCA cycle)or75 kg x 25 mg/kg = 1875 (normal dose DCA cycle).As you already know, you can count this dose quick and easy at our online dosage calculator – here.Also, you should keep in mind that you have to take it in two parts -…

How DCA works ?

For almost half a century, DCA has been a relatively basic substance used for treating people with congenital mitochondrial diseases. Nearly a decade ago, the interest in this drug spiked up because of new research and claims that it could be able to serve those who have cancer. Since then, there has been a lot of interest generated towards this medication. In this long article, we will attempt to briefly cover what we know about dichloroacetate and how it works. Keep in mind - we‘ll try to explain the complex mechanisms as simply as possible. We encourage every person interested in DCA therapy to read on. So... How does a small, inexpensive and a relatively nontoxic molecule like dichloroacetate work ? How cancer cells act differently ? To better understand the mechanism of DCA, we must be aware of the different processes that thrive in a cancerious cell. Cancer is considered to be a genetic disease in which genes that control how our cells grow and divide start behaving abnormally. Due to error in our DNA, the cells become chaotic, multiply uncontrollably and change their normal metabolic activity. Every cell contains important organelles called mitochondria. These structures can be called "cellular power plants" because they produce the energy needed for live organisms to function properly. Besides, mitochondria are important in the cells life cycle - they play key roles in activating apoptosis. Unfortunately, cancer cells have reduced mitochondrial function. This means that cancerious cells mostly produce energy by extremely high rates of glycolysis outside the mithochondria, rather than oxidative phosphorylation inside the mitochondria (Warburg effect) which also causes a massive increase in uptake of glucose and the exhaustion of the patient. Because of the intracellular metabolic changes apoptosis (natural cell death) is stopped and it makes the malignant cells "immortal". Suppressed mitochondrion function leads to a lot of advantages for the tumor - it can survive and grow without oxygen in anaerobic conditions (eg. the cells in the middle of a cancerious mass), it promotes biosynthesis (cancer growth and division), it evades immune cells and disrupts the normal architecture of tissues (the cancer becomes more malignant and dangerious). On the top of that, the Warburg effect produces an acidic environment. Such conditions damage the intercellular matrix, set the cancerious cells free into the bloodstream or lymph and promote metastasis (the cancer can spread and become deadly). As we can see, the Warburg effect causes metabolic changes that make cancer a hardly manageable ilness. Nevertheless, recently there have been ideas to begin perceiving and approaching cancer as a metabolic disease and this is where the molecule of DCA comes in handy. How DCA affects cancer ? So far we can understand how the cellular metabolism of tumors differs from that of our healthy, normal cells. Malignant cells switch off their mitochondria and start producing energy mainly through cytoplasmic glycolysis and these changes generate a lot of advantages for the tumor. Dichloroacetate works by restoring the suppressed mitochondrial function and rendering the "bad cells" noncancerous.…

What is DCA?

Sodium dichloroacetate (commonly referred to as DCA) is a salt of sodium and dichloroacetatic acid. The formula of this compound is Cl2 CH COONa. The structure of the molecule is similar to a combination of table salt and vinegar. Under normal conditions, the material appears in powder form, white color and is soluble in water. Sodium dichloroacetate is not patentable and has no restrictions on being transported, it can be freely sold without serious regulations. The compound can be synthesized in laboratories or found as a side product in chlorinated water. DCA can be naturally aquired in a variety of red algae such as Asparagopsis taxiformis. Sodium dichloroacetate has received a lot of its attention by having a beneficial biological effect on living beings. • Since 1973 Dichloroacetate has been used for treating children with congenital mitochondrial disorders (Ref.) which lead to metabolic lactic acidosis. DCA is able to treat the condition of congenital lactic acidosis and improve the life quality of such patients. The medication works by stimulating the Pyruvatdehidrogenase complex. This resumes the normal metabolism of carbohydrates through aerobic glucose and lactic acid oxidation. Children treated with DCA achieve lower concentrations of blood serum lactates as well as lower overall metabolic acidosis. The clinical trials of DCA treatment for congenital lactic acidosis hold a significant role in determining the optimal and safe concentrations for therapeutic purposes. Furthermore, side effects and the overall safety of the drug were carefully observed during the research which permitted the use of Sodium Dichloroacetate in the future. (Ref.) • Since 1987 till now there are ongoing scientific studies on treating the harmful effects of brain ischemia with the use of DCA. In such conditions, Dichloroacetate can be useful in controlling the post-hypoxic lactic acidosis and the disturbed metabolism in the brain – thus lowering the chances of a poor outcome. (Ref.) • Since 2007 the anti-cancer effect of Sodium dichloroacetate has been noted. In the early scientific studies DCA had a positive response to implanted tumours of brain, breast and lung cancer. While on the influence of Dichloroacetate, the experimental rodents did not suffer any toxic effects, however, the tumours stopped growing and later on had a drastic size reduction. (link to all DCA studies) The future in vitro and in vivo experiments had the same positive conclusions which finally lead to a clinical research in 2010. The verdict of the study - DCA has a positive effect on malignant disease outcome, the substance demonstrates potential in the treatment of cancer and it is recommended to continue further clinical observations. (Ref.) • Since 2009 DCA has been used as an alternative therapy for treating cancer in the first DCA clinics while under professional medical supervision. You can find more information and fresh news about DCA on our site or in the online research databases.

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